@article {YAMANAKA496, author = {RYOKEN YAMANAKA and YOHEI SEKINO and TAKASHI BABASAKI and KOHEI KOBATAKE and HIROYUKI KITANO and KENICHIRO IKEDA and KEISUKE GOTO and TETSUTARO HAYASHI and JUN TEISHIMA and YUKIO TAKESHIMA and YUKIKO HONDA and KAZUO AWAI and NOBUYUKI HINATA}, title = {Histopathological Analysis of False-positive Lesions in mpMRI/TRUS Fusion Prostate Biopsy}, volume = {36}, number = {1}, pages = {496--500}, year = {2022}, doi = {10.21873/invivo.12730}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Multi-parametric magnetic resonance imaging (mpMRI)/ultrasonography fusion prostate biopsy (FB) is a more accurate method of diagnosis than conventional prostate biopsy, but false-positive lesions still exist. Limited studies have examined the cause of false-positive lesions by histological analysis. Patients and Methods: We examined 322 patients who underwent mpMRI/transrectal ultrasonography (TRUS) FB. We classified prostate imaging-recording and data system (PI-RADS) 3 and PI-RADS 4-5 as low PI-RADS lesions and high PI-RADS lesions, respectively. In total, 105 lesions were identified as false-positive lesions. We performed histological analysis of atrophy, hyperplasia, and lymphocyte infiltration in these lesions, comparing low PI-RADS lesions and high PI-RADS lesions. Results: The frequencies of prostate hyperplasia and lymphocyte infiltration were higher in high PI-RADS lesions than in low PI-RADS lesions (p=0.028 and 0.024, respectively). There was no significant difference regarding atrophy (p=0.295). Conclusion: Histopathological change may be one of the reasons for false-positive lesions.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/36/1/496}, eprint = {https://iv.iiarjournals.org/content/36/1/496.full.pdf}, journal = {In Vivo} }