RT Journal Article
SR Electronic
T1 Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 49
OP 56
DO 10.21873/invivo.12675
VO 36
IS 1
A1 CHRISTA N. GRANT
A1 CARSON A. WILLS
A1 XIAOMING LIU
A1 VLADIMIR S. SPIEGELMAN
A1 HONG-GANG WANG
YR 2022
UL http://iv.iiarjournals.org/content/36/1/49.abstract
AB Background/Aim: Neuroblastoma is clinically and molecularly heterogeneous, with poor outcomes despite multimodal treatment strategies. The primary tumor site is an independent predictor of survival; adrenal tumors have the worst outcomes, while posterior mediastinum tumors carry a more favorable prognosis. Materials and Methods: To elucidate the role of the primary tumor microenvironment in mediating survival outcomes, we developed a mouse model for the study of extra-adrenal neuroblastoma by injecting luciferase-tagged cells into either the subpleural space of the posterior chest or the adrenal gland. Results: Solid tumors developed in the thoracic cavity at the same rate and efficiency as the adrenal as early as one week post-surgery. The survival rate following surgery was equivalent, though the physiological tolerance for large tumors was lower in the thoracic group. Conclusion: This novel mouse model of survivable extra-adrenal neuroblastoma will enable future investigations of the distinct tumor microenvironments between the adrenal gland and posterior mediastinum.