TY - JOUR T1 - Left-sided Breast Cancer Irradiation With Deep Inspiration Breath-hold: Changes in Heart and Lung Dose in Two Periods JF - In Vivo JO - In Vivo SP - 314 LP - 324 DO - 10.21873/invivo.12704 VL - 36 IS - 1 AU - ANNE CAROLINE KNÖCHELMANN AU - NESE CEYLAN AU - MICHAEL BREMER Y1 - 2022/01/01 UR - http://iv.iiarjournals.org/content/36/1/314.abstract N2 - Background/Aim: Post-operative radiotherapy for breast cancer can increase cardiac disease in a dose-dependent manner. In this study we show the reduction of dose to heart and left anterior descending artery (LAD) which can be achieved by using “Deep inspiration breath-hold” (DIBH) technique. Patients and Methods: Tangential 3D-planned radiation was delivered to 357 patients with left-sided breast cancer, 159 of them with the DIBH technique. A distinction was made according to fractionation scheme. Results: The mean heart dose was significantly reduced by DIBH from 2.64 Gy to 1.39 Gy (p<0.001). The mean dose to the LAD was significantly reduced from 5.68 Gy to 3.88 Gy (p<0.001). Mean dose and volume receiving 5, 10 and 15 Gy of ipsilateral lung were higher with both hypofractionated schedule and conventional fractionation in the DIBH group. Conclusion: DIBH in left-sided breast irradiation is an effective method of reducing the radiogenic heart dose. ER -