RT Journal Article SR Electronic T1 Impressive Long-term Response with Pertuzumab and Trastuzumab in HER2-positive Breast Cancer with Brain Metastasis JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 839 OP 842 DO 10.21873/invivo.11317 VO 32 IS 4 A1 MICHELANGELO RUSSILLO A1 GIANLUIGI FERRETTI A1 ANTONELLO VIDIRI A1 SIMONA GASPARRO A1 FRANCESCO COGNETTI A1 DOMENICA PELLEGRINI A1 ALESSANDRA FABI YR 2018 UL http://iv.iiarjournals.org/content/32/4/839.abstract AB This is a case report of a 40-year-old woman who, after conservative breast cancer treatment, developed a HER2 positive solitary brain metastasis in the left temporal lobe, without extracranial disease. She underwent surgery resection followed by stereotactic radiotherapy and, because of early brain progression, she was submitted to the first line therapy with pertuzumab, trastuzumab and weekly paclitaxel. After six months of treatment, a brain magnetic resonance imaging revealed a complete disappearance of brain recurrence, which persisted for more than 24 months.