TY - JOUR T1 - Impressive Long-term Response with Pertuzumab and Trastuzumab in HER2-positive Breast Cancer with Brain Metastasis JF - In Vivo JO - In Vivo SP - 839 LP - 842 DO - 10.21873/invivo.11317 VL - 32 IS - 4 AU - MICHELANGELO RUSSILLO AU - GIANLUIGI FERRETTI AU - ANTONELLO VIDIRI AU - SIMONA GASPARRO AU - FRANCESCO COGNETTI AU - DOMENICA PELLEGRINI AU - ALESSANDRA FABI Y1 - 2018/07/01 UR - http://iv.iiarjournals.org/content/32/4/839.abstract N2 - This is a case report of a 40-year-old woman who, after conservative breast cancer treatment, developed a HER2 positive solitary brain metastasis in the left temporal lobe, without extracranial disease. She underwent surgery resection followed by stereotactic radiotherapy and, because of early brain progression, she was submitted to the first line therapy with pertuzumab, trastuzumab and weekly paclitaxel. After six months of treatment, a brain magnetic resonance imaging revealed a complete disappearance of brain recurrence, which persisted for more than 24 months. ER -