TY - JOUR T1 - Hemodynamic Alteration in the Liver in Acute Hepatitis: A Quantitative Evaluation Using Computed Tomographic Perfusion JF - In Vivo JO - In Vivo SP - 3537 LP - 3545 DO - 10.21873/invivo.12656 VL - 35 IS - 6 AU - AKIHIRO NISHIE AU - YASUHIRO USHIJIMA AU - YUKIHISA TAKAYAMA AU - NOBUHIRO FUJITA AU - YUICHIRO KUBO AU - KEISUKE ISHIMATSU AU - DAISUKE TSURUMARU AU - MOTOYUKI KOHJIMA AU - KOUSEI ISHIGAMI Y1 - 2021/11/01 UR - http://iv.iiarjournals.org/content/35/6/3537.abstract N2 - Background/Aim: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging. Patients and Methods: For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors. Results: The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=–0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02). Conclusion: The PI of the right liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure. ER -