RT Journal Article
SR Electronic
T1 Lipomatous Meningioma: Clinical-Pathological Findings, Imaging Characterisation and Correlations of a Rare Type of Meningioma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3031
OP 3037
DO 10.21873/invivo.12598
VO 35
IS 6
A1 PIERFRANCESCO LAPOLLA
A1 PIETRO FAMILIARI
A1 GIUSEPPA ZANCANA
A1 PLACIDO BRUZZANITI
A1 RUI CHEN
A1 XIAOBO LI
A1 GIUSEPPE FAMILIARI
A1 ANTONIO SANTORO
YR 2021
UL http://iv.iiarjournals.org/content/35/6/3031.abstract
AB Lipomatous meningioma (LM) is a form of metaplasia, originating from intracellular lipid bodies accumulation due to metabolic alterations. A comprehensive literature review was performed introducing further elements of evaluation. The parameters utilized were age, sex, location, clinical presentation, imaging features, treatment, and recurrences. Seizure and headache are the primary onsets of symptoms. Further LM clinical features, such as visual disturbances and visual epileptic seizures were examined. Symptoms may occur ten years prior to LM finding and it can resolve completely with the indicated surgery. LM computed tomography imaging analysis reveals hypodense regions due to the presence of fat content. On magnetic resonance imaging, the lesion displays hyperintense signal in T1-T2 with signal loss in the fat-suppression sequences. Immunohistochemically, lipidized meningioma cells are positive for Epithelial-Membrane Antigen, Vimentin, CD99, S-100 protein, and progesterone receptor. The recurrence risk rate of LM is estimated to be around 17%. Precise immune-histological findings have been correlated with imaging features to help with early diagnosis. A defined diagnosis of LM is a crucial factor in the choice of treatment.