RT Journal Article
SR Electronic
T1 Tumour Markers in the Differential Diagnosis of Patients With Isolated Involuntary Weight Loss
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3361
OP 3367
DO 10.21873/invivo.12634
VO 35
IS 6
A1 JAUME TRAPE
A1 JORDI ALIGUE
A1 MIREIA VICENTE
A1 ANNA ARNAU
A1 ANTONIO SAN-JOSE
A1 JOSEP ORDEIG
A1 ROSER ORDEIG
A1 MARIONA BONET
A1 ANDRES ABRIL
A1 OMAR EL-BOUTROUKI
A1 CAROLINA GONZALEZ-FERNANDEZ
A1 MARIA SALA
A1 CRISTINA FIGOLS
A1 ELISABETH GONZALEZ-GARCIA
A1 LOURDES MONTSANT
A1 DOMINGO RUIZ
YR 2021
UL http://iv.iiarjournals.org/content/35/6/3361.abstract
AB Background/Aim: Paraneoplastic syndrome symptoms include isolated involuntary weight loss (IIWL). The differential diagnosis of cancer from other diseases may require a significant number of tests. Tumour markers (TMs) can be used for the diagnosis and stratification of patients according to cancer risk. Patients and Methods: This study included 606 patients (48% females) seen at the rapid diagnostic unit for IIWL. We determined the levels of TMs carcinoembryonic antigen, carbohydrate antigen 19-9, soluble fragments of cytokeratin 19, carbohydrate antigen 15-3, carbohydrate antigen 125, neuron specific enolase, alpha-fetoprotein, prostatic specific antigen using the multiparametric analyser COBAS 601. Two cut-off points were established, the upper reference limit described by the manufacturer and a high cut-off point suggested by Molina et al., to stratify patients according to cancer risk. Results: Patients were classified according to TM levels as follows: I) all TMs below the upper reference limit; II) highest number of TMs between the two cut-offs; III) at least one TM above the higher cut-off. The odds ratio for malignancy was 4.3 for group II and 248 for group III. These results indicate that when at least one TM is above the higher cut-off, neoplasia is highly probable. Conclusion: TM determination allowed to establish cancer risk in patients with IIWL.