TY - JOUR T1 - Tumour Markers in the Differential Diagnosis of Patients With Isolated Involuntary Weight Loss JF - In Vivo JO - In Vivo SP - 3361 LP - 3367 DO - 10.21873/invivo.12634 VL - 35 IS - 6 AU - JAUME TRAPE AU - JORDI ALIGUE AU - MIREIA VICENTE AU - ANNA ARNAU AU - ANTONIO SAN-JOSE AU - JOSEP ORDEIG AU - ROSER ORDEIG AU - MARIONA BONET AU - ANDRES ABRIL AU - OMAR EL-BOUTROUKI AU - CAROLINA GONZALEZ-FERNANDEZ AU - MARIA SALA AU - CRISTINA FIGOLS AU - ELISABETH GONZALEZ-GARCIA AU - LOURDES MONTSANT AU - DOMINGO RUIZ Y1 - 2021/11/01 UR - http://iv.iiarjournals.org/content/35/6/3361.abstract N2 - Background/Aim: Paraneoplastic syndrome symptoms include isolated involuntary weight loss (IIWL). The differential diagnosis of cancer from other diseases may require a significant number of tests. Tumour markers (TMs) can be used for the diagnosis and stratification of patients according to cancer risk. Patients and Methods: This study included 606 patients (48% females) seen at the rapid diagnostic unit for IIWL. We determined the levels of TMs carcinoembryonic antigen, carbohydrate antigen 19-9, soluble fragments of cytokeratin 19, carbohydrate antigen 15-3, carbohydrate antigen 125, neuron specific enolase, alpha-fetoprotein, prostatic specific antigen using the multiparametric analyser COBAS 601. Two cut-off points were established, the upper reference limit described by the manufacturer and a high cut-off point suggested by Molina et al., to stratify patients according to cancer risk. Results: Patients were classified according to TM levels as follows: I) all TMs below the upper reference limit; II) highest number of TMs between the two cut-offs; III) at least one TM above the higher cut-off. The odds ratio for malignancy was 4.3 for group II and 248 for group III. These results indicate that when at least one TM is above the higher cut-off, neoplasia is highly probable. Conclusion: TM determination allowed to establish cancer risk in patients with IIWL. ER -