TY - JOUR T1 - Cytogenetic Biomonitoring in Buccal Mucosa Cells of COVID-19 Patients: Preliminary Findings JF - In Vivo JO - In Vivo SP - 3495 LP - 3499 DO - 10.21873/invivo.12651 VL - 35 IS - 6 AU - THIAGO GUEDES PINTO AU - MARIA ESTHER SUAREZ ALPIRE AU - DANIEL ARAKI RIBEIRO Y1 - 2021/11/01 UR - http://iv.iiarjournals.org/content/35/6/3495.abstract N2 - Background/Aim: COVID-19 may lead to progressive respiratory failure as a consequence of alveolar damage, resulting in death. The aim of this study was to evaluate cytogenetic damage in oral cells of COVID-19 patients by micronucleus assay. Patients and Methods: A total of 11 COVID-19 patients aged 40.7±9.3 years (5 men and 6 women) were included in this study. For the control group, a total of 15 participants not infected with SARS-CoV-2 virus were included. The mean age was 41.6±6.2 years (5 men and 10 women). Results: The results showed statistically significant differences (p<0.05) in micronucleated buccal mucosa cells of COVID-19 patients. In addittion, a statistically significant increase in karyolysis and karrhyorexis (p<0.05) was observed in COVID-19 patients compared to control. Conclusion: SARS-CoV-2 virus can induce mutagenesis and cytotoxicity in oral cells. ER -