TY - JOUR T1 - Curcumin Derivative MTH-3 Regulates Palmitate-induced Insulin Resistance in Mouse Myoblast C<sub>2</sub>C<sub>12</sub> Cells JF - In Vivo JO - In Vivo SP - 3181 LP - 3191 DO - 10.21873/invivo.12613 VL - 35 IS - 6 AU - YU-JEN CHIU AU - YU-HSIANG LO AU - JAI-SING YANG AU - SHENG-CHU KUO AU - SHIH-CHANG TSAI Y1 - 2021/11/01 UR - http://iv.iiarjournals.org/content/35/6/3181.abstract N2 - Background/Aim: At present, there are no effective drugs for the treatment of insulin resistance. MTH-3, a curcumin derivative, exerts potent anti-cancer effects. The aim of the present study was to explore whether MTH-3 is capable of regulating palmitic acid (PA)-induced insulin resistance in C2C12 cells. Materials and Methods: Cell viability was examined using the MTT assay. C2C12 cells were treated with PA and evaluated for the production of oil droplets using an Oil Red O assay. Glucose uptake was analysed by the 2-NBDG assay. Results: Treatment of cells with up to 500 μM PA for 24 h or with 5 or 10 μM MTH-3 had no effect on cell viability. PA induced production of oil droplets in C2C12 cells. After adding MTH-3, the quantity of oil droplets decreased significantly and glucose uptake recovered. Conclusion: MTH-3 may become an efficient drug for the treatment of insulin resistance and associated diseases. ER -