RT Journal Article
SR Electronic
T1 Influence of Radiation Dose and Reconstruction Kernel on Fat Fraction Analysis in Dual-energy CT: A Phantom Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3147
OP 3155
DO 10.21873/invivo.12609
VO 35
IS 6
A1 CHATZARAKI, VASILIKI
A1 BORN, CORINNA
A1 KUBIK-HUCH, RAHEL A.
A1 FROEHLICH, JOHANNES M.
A1 THALI, MICHAEL J.
A1 NIEMANN, TILO
YR 2021
UL http://iv.iiarjournals.org/content/35/6/3147.abstract
AB Background/Aim: The quantitative evaluation of fat tissue, mainly for the determination of liver steatosis, is possible by using dual-energy computed tomography. Different photon energy acquisitions allow for estimation of attenuation coefficients. The effect of variation in radiation doses and reconstruction kernels on fat fraction estimation was investigated. Materials and Methods: A six-probe-phantom with fat concentrations of 0%, 20%, 40%, 60%, 80%, and 100% were scanned in Sn140/100 kV with radiation doses ranging between 20 and 200 mAs before and after calibration. Images were reconstructed using iterative kernels (I26,Q30,I70). Results: Fat fractions measured in dual-energy computed tomography (DECT) were consistent with the 20%-stepwise varying actual concentrations. Variation in radiation dose resulted in 3.1% variation of fat fraction. Softer reconstruction kernel (I26) underestimated the fat fraction (–9.1%), while quantitative (Q30) and sharper kernel (I70) overestimated fat fraction (10,8% and 13,1, respectively). Conclusion: The fat fraction in DECT approaches the actual fat concentration when calibrated to the reconstruction kerneö. Variation of radiation dose caused an acceptable 3% variation.