RT Journal Article SR Electronic T1 Impact of Intraoperative Blood Loss on the Survival of Patients With Stage II/III Colorectal Cancer: A Multicenter Retrospective Study JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 3483 OP 3488 DO 10.21873/invivo.12649 VO 35 IS 6 A1 HIROSHI TAMAGAWA A1 MASAKATSU NUMATA A1 TORU AOYAMA A1 KEISUKE KAZAMA A1 YOSUKE ATSUMI A1 KENTA IGUCHI A1 SHO SAWAZAKI A1 SUMITO SATO A1 KAZUKI KANO A1 TAKASHI OHSHIMA A1 TAKANOBU YAMADA A1 TENI GODAI A1 AKIO HIGUCHI A1 HIROYUKI SAEKI A1 NORIO YUKAWA A1 YASUSHI RINO YR 2021 UL http://iv.iiarjournals.org/content/35/6/3483.abstract AB Background: Resection of the primary lesion with radical lymph node dissection is the most promising treatment avenue for patients with cancer. On the other hand, these procedures often induce excessive intraoperative blood loss (IBL) and require perioperative blood transfusion. The influence of IBL on the long-term postoperative outcomes of patients with digestive cancer is controversial. We investigated the impact of IBL on survival and recurrence after curative surgery in patients with colorectal cancer (CRC) in a single study group. Patients and Methods: In total, 1,597 patients who underwent radical resection for CRC at three group hospitals between 2000 and 2019 were reviewed. Patients were classified into a group with high IBL (≥200 ml) or low IBL (<200 ml). The risk factors for disease-free (DFS) and overall (OS) survival were analyzed. Results: A total of 489 and 1,108 patients were classified into the high and low IBL groups, respectively. The OS and DFS rates at 5 years after surgery were 89.3% and 63.4%, respectively, for the high IBL group and 96.9% and 77.8% for the low IBL group; these differences were statistically significantly (p<0.001). The multivariate analysis demonstrated that IBL was a significant independent risk factor for OS and DFS. Conclusion: The amount of IBL was associated with significant differences in the OS and DFS of patients with stage II/III CRC who received curative resection. The surgical procedure, surgical strategy, and perioperative care should be carefully planned to avoid causing IBL.