RT Journal Article
SR Electronic
T1 Acute Lymphoblastic Leukemia in Children: Better Transplant Outcomes After Total Body Irradiation-based Conditioning
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3315
OP 3320
DO 10.21873/invivo.12627
VO 35
IS 6
A1 JAN STYCZYNSKI
A1 ROBERT DEBSKI
A1 KRZYSZTOF CZYZEWSKI
A1 KATARZYNA GAGOLA
A1 EWA MARQUARDT
A1 KRZYSZTOF ROSZKOWSKI
A1 JANUSZ WINIECKI
A1 NINELA IRGA-JAWORSKA
A1 MARCIN HENNIG
A1 KATARZYNA MUSZYNSKA-ROSLAN
A1 MARCIN PLONOWSKI
A1 TOMASZ OCIEPA
A1 MONIKA LECKA
A1 JOANNA KONIECZEK
A1 PRZEMYSLAW GALAZKA
A1 MONIKA POGORZALA
A1 MONIKA RICHERT-PRZYGONSKA
A1 MARIUSZ WYSOCKI
YR 2021
UL http://iv.iiarjournals.org/content/35/6/3315.abstract
AB Background/Aim: Comparison of transplant outcomes in long-term follow-up of children after total body irradiation (TBI)- or chemotherapy-based conditioning allogeneic hematopoietic cell transplantation (allo-HCT). Patients and Methods: Patients undergoing allo-HCT for Acute lymphoblastic leukemia (ALL) conditioned either with TBI (n=55) or chemotherapy (n=84) were compared. The following transplant outcomes were analyzed: overall survival (OS), event-free survival (EFS), relapse incidence (RI), and graft-versus-host-disease (GVHD)-free-relapse-free survival (GRFS). Results: All analyzed long-term transplant outcomes were significantly better for patients conditioned with TBI at 2 years after transplant. OS at 2 years was 84% after TBI and 60.5% after chemotherapy-conditioning (p=0.005). Risk factor analysis showed that two factors, TBI-based conditioning and transplant in first remission of ALL, significantly improved OS, EFS, GRFS, and decreased RI. Conclusion: TBI-based conditioning before allogeneic HCT in children with acute lymphoblastic leukemia provides significantly better transplant outcomes, when compared to chemotherapy-based conditioning.