TY - JOUR T1 - Acute Lymphoblastic Leukemia in Children: Better Transplant Outcomes After Total Body Irradiation-based Conditioning JF - In Vivo JO - In Vivo SP - 3315 LP - 3320 DO - 10.21873/invivo.12627 VL - 35 IS - 6 AU - JAN STYCZYNSKI AU - ROBERT DEBSKI AU - KRZYSZTOF CZYZEWSKI AU - KATARZYNA GAGOLA AU - EWA MARQUARDT AU - KRZYSZTOF ROSZKOWSKI AU - JANUSZ WINIECKI AU - NINELA IRGA-JAWORSKA AU - MARCIN HENNIG AU - KATARZYNA MUSZYNSKA-ROSLAN AU - MARCIN PLONOWSKI AU - TOMASZ OCIEPA AU - MONIKA LECKA AU - JOANNA KONIECZEK AU - PRZEMYSLAW GALAZKA AU - MONIKA POGORZALA AU - MONIKA RICHERT-PRZYGONSKA AU - MARIUSZ WYSOCKI Y1 - 2021/11/01 UR - http://iv.iiarjournals.org/content/35/6/3315.abstract N2 - Background/Aim: Comparison of transplant outcomes in long-term follow-up of children after total body irradiation (TBI)- or chemotherapy-based conditioning allogeneic hematopoietic cell transplantation (allo-HCT). Patients and Methods: Patients undergoing allo-HCT for Acute lymphoblastic leukemia (ALL) conditioned either with TBI (n=55) or chemotherapy (n=84) were compared. The following transplant outcomes were analyzed: overall survival (OS), event-free survival (EFS), relapse incidence (RI), and graft-versus-host-disease (GVHD)-free-relapse-free survival (GRFS). Results: All analyzed long-term transplant outcomes were significantly better for patients conditioned with TBI at 2 years after transplant. OS at 2 years was 84% after TBI and 60.5% after chemotherapy-conditioning (p=0.005). Risk factor analysis showed that two factors, TBI-based conditioning and transplant in first remission of ALL, significantly improved OS, EFS, GRFS, and decreased RI. Conclusion: TBI-based conditioning before allogeneic HCT in children with acute lymphoblastic leukemia provides significantly better transplant outcomes, when compared to chemotherapy-based conditioning. ER -