RT Journal Article
SR Electronic
T1 Combination of the CD8<sup>+</sup>:B-cell and Neutrophil-to-Lymphocyte Ratio as a Novel Prediction Model for Intubation Need and Disease Severity in COVID-19 Patients
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3305
OP 3313
DO 10.21873/invivo.12626
VO 35
IS 6
A1 MARIA G. DETSIKA
A1 EIRINI GRIGORIOU
A1 KATHERINA PSARRA
A1 EDISON JAHAJ
A1 STAMATIOS TSIPILIS
A1 NIKOLAOS ATHANASSIOU
A1 ALEXANDROS ZACHARIS
A1 IOANNA DIMOPOULOU
A1 STYLIANOS E. ORFANOS
A1 ALEXANDRA TSIROGIANNI
A1 ANASTASIA KOTANIDOU
YR 2021
UL http://iv.iiarjournals.org/content/35/6/3305.abstract
AB Background: The study provides a novel prediction model for COVID-19 progression and outcome by the combination of the CD8+: B-cells ratio with neutrophil-to-lymphocyte ratio (NLR). Patients and Methods: Immune phenotyping was performed in 120 COVID-19 patients. Results: A decrease in CD8+:B-cell (p&lt;0.0001) and in lymphocyte-to-CRP (LCR) ratio (p&lt;0.0001) was observed in intubated patients versus non-intubated with an increase for CD4+:CD8+ (p&lt;0.01), NLR (p&lt;0.0001) and CRP: Albumin (p&lt;0.001). Receiving operating curve (ROC) analysis predicting requirement for mechanical ventilation revealed the highest AUC for CD8+:B-cells, (AUC=0.795, p&lt;0.001) versus NLR (AUC=0.783, p&lt;0.001), LCR (AUC=0.779, p&lt;0.001), Albumin:CRP (AUC=0.750, p&lt;0.001) and CD4+:CD8+ (AUC=0.779, p&lt;0.001). Combination of the CD8+: B-cell ratio with the NLR increased the AUC (AUC=0.845, p&lt;0.001). The combined ratios correlated with outcome defined as duration of hospital (r=0.435, p&lt;0.001) or ICU stay (r=0.596, p&lt;0.001). Conclusion: Combination of the CD8+: B-cell ratio and NLR serves as a useful prognostic tool for COVID-19 patient progression.