PT  - JOURNAL ARTICLE
AU  - CHENG-HSI LIAO
AU  - CHIA-WEN TSAI
AU  - WEN-SHIN CHANG
AU  - ZHI-HONG WANG
AU  - CHI-LI GONG
AU  - HSI-CHIN WU
AU  - BO-REN WANG
AU  - SHIH-WEI HSU
AU  - WEN-CHIN HUANG
AU  - TE-CHUN SHEN
AU  - DA-TIAN BAU
TI  - Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk
AID  - 10.21873/invivo.12535
DP  - 2021 Sep 01
TA  - In Vivo
PG  - 2535--2540
VI  - 35
IP  - 5
4099  - http://iv.iiarjournals.org/content/35/5/2535.short
4100  - http://iv.iiarjournals.org/content/35/5/2535.full
SO  - In Vivo2021 Sep 01; 35
AB  - Aim: There is very little literature reporting the association of matrix metalloproteinase-1 (MMP1) with personal susceptibility to bladder cancer. In the current study, we carried out the first examination of the contribution of MMP1 rs1799750 to bladder cancer risk in Taiwanese. Materials and Methods: A total of 375 bladder cancer cases and 375 healthy controls were genotyped for MMP1 rs1799750 via polymerase chain reaction-restriction fragment length polymorphism methodology and this was evaluated for association with clinicopathological factors. Results: The frequencies of MMP1 rs1799750 2G/2G, 1G/2G, and 1G/1G genotypes were 35.7%, 44.8% and 19.5% in the group with bladder cancer and 32.5%, 46.4%, and 21.1% in the healthy control group (p for trend=0.6362). The odds ratios (ORs) for bladder cancer risk after adjusting for age and gender for those carrying 1G/2G and 1G/1G genotypes at MMP1 rs1799750 were 0.88 (95% CI=0.62-1.24, p=0.4357) and 0.83 (95% CI=0.61-1.26, p=0.3990), respectively, compared with the wild-type 2G/2G genotype. In allelic frequency analysis, the adjusted OR for those carrying the 1G allele at MMP1 rs1799750 was 0.87 (95% CI=0.71-1.23, p=0.3479) compared to those people carrying a 2G allele. Conclusion: Our findings indicated that the genotypes at MMP1 rs1799750 appear to play little role in determining personal susceptibility to bladder cancer for Taiwanese.