PT  - JOURNAL ARTICLE
AU  - HIDEYUKI HONGO
AU  - KOICHI TOKUUE
AU  - TAKEJI SAKAE
AU  - MISATO MASE
AU  - MOTOKO OMURA
TI  - Robust Treatment Planning in Intrafraction Motion Using TomoDirect™ Intensity-modulated Radiotherapy for Breast Cancer
AID  - 10.21873/invivo.12548
DP  - 2021 Sep 01
TA  - In Vivo
PG  - 2655--2659
VI  - 35
IP  - 5
4099  - http://iv.iiarjournals.org/content/35/5/2655.short
4100  - http://iv.iiarjournals.org/content/35/5/2655.full
SO  - In Vivo2021 Sep 01; 35
AB  - Background/Aim: To evaluate the robustness of radiotherapy treatment planning optimization for respiratory-moving breast cancer using fixed-angle beams planning TomoDirect™ intensity-modulated radiotherapy (IMRT). Materials and Methods: A minimax optimisation algorithm was applied to 10 breast cancer patients. Two sets of treatment plans with or without robust techniques were prepared considering anterior-posterior and head-tail movements due to respiration. Parameters were compared between treatment plans: 95% planned target volume (PTV) dose, conformal index and homogeneity index (HI), and organs at risk (OAR) parameters including the lung volume receiving 20 Gy or more (V20) and 5 Gy (V5). Results: Robust planning significantly improved parameters of 95% PTV dose and HI, without deteriorating V20 or V5 in the anterior-posterior movement, while it slightly improved 95% PTV and slightly deteriorated V20 in the head-tail movement. Conclusion: Robust treatment planning improves coverage of targets moving because of respiration in the treatment of breast cancer using TomoDirect; however, normal lung doses should be cautiously evaluated on a case-by-case basis.