TY - JOUR T1 - Establishment of an Experimental System for Intraperitoneal Chemotherapy in a Rat Model JF - In Vivo JO - In Vivo SP - 2703 LP - 2710 DO - 10.21873/invivo.12554 VL - 35 IS - 5 AU - SUNWOO PARK AU - SOO JIN PARK AU - HEE SU LEE AU - JIYEON HAM AU - EUN JI LEE AU - JUNSIK KIM AU - SOOMIN RYU AU - AERAN SEOL AU - WHASUN LIM AU - JUNG CHAN LEE AU - GWONHWA SONG AU - HEE SEUNG KIM Y1 - 2021/09/01 UR - http://iv.iiarjournals.org/content/35/5/2703.abstract N2 - Aim: To establish an experimental system for comparing different methods of intraperitoneal chemotherapy in a rat model. Materials and Methods: We used six-week-old Sprague–Dawley rats, and created an early postoperative intraperitoneal chemotherapy (EPIC) system using 18-gauge syringes and evacuators, and a hyperthermic intraperitoneal chemotherapy (HIPEC) system using two peristaltic pumps which controlled the flow rate and temperature. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) was achieved using a nozzle for dispersing aerosols at a flow rate up to 41.5 ml/min. The distribution and intensity of 0.2% trypan blue dye was compared among three methods. Results: The distribution was limited and the intensity was weak after EPIC, and the dye stained moderately in gravity-dependent regions after HIPEC. On the other hand, the distribution was the most comprehensive, and the intensity was the greatest after PIPAC. Conclusion: This experimental system in a rat model may reflect the comparative effect among EPIC, HIPEC and PIPAC in humans. ER -