TY - JOUR T1 - Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients JF - In Vivo JO - In Vivo SP - 2755 LP - 2762 DO - 10.21873/invivo.12560 VL - 35 IS - 5 AU - KATHARINA LEDITZKE AU - MAXIMILIAN EBERHARD HERMANN WAGNER AU - CLAUDIA NEUNABER AU - JAN-DIERK CLAUSEN AU - MARCEL WINKELMANN Y1 - 2021/09/01 UR - http://iv.iiarjournals.org/content/35/5/2755.abstract N2 - Background: Early detection of acute kidney injury (AKI) is crucial in the management of multiple-organ dysfunction syndrome in severely injured patients. Standard laboratory parameters usually increase with temporal delay. Therefore, we evaluated neutrophil gelatinase-associated lipocalin (NGAL) as an early marker for acute kidney injury. Patients and Methods: We retrospectively evaluated patients admitted to a level 1 trauma center. We collected clinicodemographic data and measured kidney-related factors and plasma cytokines. Results: A total of 39 patients were included. Patients with AKI had significantly higher levels not only of serum creatinine and urea, but also of NGAL (all p<0.001) than patients without AKI. The optimal NGAL cut-off value was determined to be 177 ng/ml, showing significant correlation with imminent or manifest AKI (p<0.001). Other independent markers correlated with AKI included pre-existing chronic kidney disease, use of catecholamines, and severe injury (p<0.001). Conclusion: The serum level of NGAL is feasible early predictor of AKI. ER -