RT Journal Article
SR Electronic
T1 In Vitro and Ex Vivo Analysis of Collagen Foams for Soft and Hard Tissue Regeneration
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2541
OP 2549
DO 10.21873/invivo.12536
VO 35
IS 5
A1 OLE JUNG
A1 MIKE BARBECK
A1 LU FAN
A1 FABIAN KORTE
A1 CUIFENG ZHAO
A1 RUMEN KRASTEV
A1 SVEN PANTERMEHL
A1 XIN XIONG
YR 2021
UL http://iv.iiarjournals.org/content/35/5/2541.abstract
AB Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.