RT Journal Article
SR Electronic
T1 Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2947
OP 2949
DO 10.21873/invivo.12587
VO 35
IS 5
A1 TAKAO KITAGAWA
A1 MASANOBU KOBAYASHI
A1 TOHRU OHTA
A1 MASARU TERASAKI
A1 YOKO TSUKAMOTO
A1 RIE TAKAI
A1 REIKA ISHIZUMI
A1 OSAMU UEHARA
A1 KOJI NAKAGAWA
A1 KOZO AKINO
A1 MASAHIRO ASAKA
A1 YASUHIRO KURAMITSU
YR 2021
UL http://iv.iiarjournals.org/content/35/5/2947.abstract
AB Background/Aim: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been affecting Hokkaido, Japan since late February 2020 until present. The aim of this study was to report the relationship between anti-SARS-CoV-2 antibody-positive and SARS-CoV-2 PCR-positive cases by analyzing anti-SARS-CoV-2 antibodies (IgG and total-Ig). Patients and Methods: Serum samples were collected from care workers and nurses in two nursing homes and two hospitals which underwent virus outbreak. All people were confirmed to be SARS-CoV-2-positive by RT-qPCR and their sera was analyzed for anti-SARS-CoV-2 antibodies (IgG and total-Ig). Results: Although 34 out of 43 samples (79.1%) showed enough amount of anti-SARS-CoV-2 antibodies, 9 RT-qPCR -positive samples (20.9%) showed absence of anti-SARS-CoV-2 antibodies in their sera. Conclusion: The results that 20.9% of RT-qPCR-positive samples with SARS-CoV-2 showed absence of anti-SARS-CoV-2 antibodies provides a possibility that the innate immune reaction could eliminate the virus without activating adaptive immune reaction.