RT Journal Article SR Electronic T1 Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2503 OP 2511 DO 10.21873/invivo.12531 VO 35 IS 5 A1 ZUBIN HE A1 GUOCHAO YIN A1 QINGDI QUENTIN LI A1 QIONGFANG ZENG A1 JINLIANG DUAN YR 2021 UL http://iv.iiarjournals.org/content/35/5/2503.abstract AB The metabolic disorders caused by diabetes can lead to various complications, including dysfunction of the male reproductive system. In patients with diabetes, long-term hyperglycemia results in diabetic vascular neuropathy, oxidative stress injury, abnormal zinc metabolism, and insulin resistance syndrome. In addition, insulin deficiency and resistance in diabetes can damage the hypothalamus, pituitary gland, gonads, and perigonads. This can reduce the secretion of sex hormones including gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone, and testosterone, and can lead to testicular atrophy, stromal cell atrophy, seminiferous tubule damage, spermatogenic cell damage, and other structural injuries of the male reproductive organs. These actions can affect male fertility and reproductive health. Herein, we review studies that report a causative role of diabetes in male reproductive function. We also discuss the evidence-based mechanisms involved in the processes of diabetes-related male sexual and reproductive dysfunction as well as the progress in treatment.