RT Journal Article
SR Electronic
T1 Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2041
OP 2046
DO 10.21873/invivo.12473
VO 35
IS 4
A1 CHIA-HSIANG LI
A1 KUO-LIANG CHIU
A1 TE-CHUN HSIA
A1 TE-CHUN SHEN
A1 LI-HSIOU CHEN
A1 CHIEN-CHIH YU
A1 MEI-CHIN MONG
A1 WEN-SHIN CHANG
A1 CHIA-WEN TSAI
A1 DA-TIAN BAU
YR 2021
UL http://iv.iiarjournals.org/content/35/4/2041.abstract
AB Background/Aim: The molecular mechanisms underlying the association between cell cycle and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in asthma airway smooth muscle. We investigated whether the most frequently examined functional variants in CCND1 determine asthma susceptibility. Materials and Methods: We genotyped 651 participants for single-nucleotide polymorphisms (SNPs) at rs9344 and rs678653 on CCND1 and assessed the association of these SNPs with asthma risk. Results: Significant differences were found in the distributions of genotypic (p=0.0064) and allelic (p=0.0021) frequencies of CCND1 rs9344. In addition, AG or GG carriers had 0.63- or 0.48-fold adjusted odds ratios for asthma risk (95%confidence intervals=0.48-0.92 and 0.22-0.78, respectively) than those who carried the AA wildtype. Conclusion: Our results suggest that cell cycle regulation may play a role in asthma initiation and development, and the CCND1 rs9344 genotype may serve as an early detection marker for asthma.