PT  - JOURNAL ARTICLE
AU  - CHIA-HSIANG LI
AU  - KUO-LIANG CHIU
AU  - TE-CHUN HSIA
AU  - TE-CHUN SHEN
AU  - LI-HSIOU CHEN
AU  - CHIEN-CHIH YU
AU  - MEI-CHIN MONG
AU  - WEN-SHIN CHANG
AU  - CHIA-WEN TSAI
AU  - DA-TIAN BAU
TI  - Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan
AID  - 10.21873/invivo.12473
DP  - 2021 Jul 01
TA  - In Vivo
PG  - 2041--2046
VI  - 35
IP  - 4
4099  - http://iv.iiarjournals.org/content/35/4/2041.short
4100  - http://iv.iiarjournals.org/content/35/4/2041.full
SO  - In Vivo2021 Jul 01; 35
AB  - Background/Aim: The molecular mechanisms underlying the association between cell cycle and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in asthma airway smooth muscle. We investigated whether the most frequently examined functional variants in CCND1 determine asthma susceptibility. Materials and Methods: We genotyped 651 participants for single-nucleotide polymorphisms (SNPs) at rs9344 and rs678653 on CCND1 and assessed the association of these SNPs with asthma risk. Results: Significant differences were found in the distributions of genotypic (p=0.0064) and allelic (p=0.0021) frequencies of CCND1 rs9344. In addition, AG or GG carriers had 0.63- or 0.48-fold adjusted odds ratios for asthma risk (95%confidence intervals=0.48-0.92 and 0.22-0.78, respectively) than those who carried the AA wildtype. Conclusion: Our results suggest that cell cycle regulation may play a role in asthma initiation and development, and the CCND1 rs9344 genotype may serve as an early detection marker for asthma.