RT Journal Article SR Electronic T1 Clinical Significance of Composition Changes in T-cell Subpopulations After Chemotherapy in Patients With Gastric Cancer JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2417 OP 2424 DO 10.21873/invivo.12519 VO 35 IS 4 A1 MIN-KYUNG YEO A1 PUREUM SUN A1 CHAEUK CHUNG A1 JAE HO PARK A1 SUN HYUNG KANG A1 HEE SEOK MOON A1 JAE KYU SUNG A1 HYUN YONG JEONG A1 JU SEOK KIM YR 2021 UL http://iv.iiarjournals.org/content/35/4/2417.abstract AB Background/Aim: New therapeutic agents and prognostic biomarkers for gastric cancer are needed. We analyzed the composition of peripheral blood T-cell subpopulations in response to chemotherapy in patients with gastric cancer. Patients and Methods: Peripheral blood samples were collected from patients diagnosed with gastric cancer before and after chemotherapy (FOLFOX; oxaliplatin, 5-fluorouracil, and leucovorin). Peripheral blood mononuclear cells were isolated. Patients were divided into responder (n=5) and non-responder groups (n=2) based on their chemotherapy outcomes. Results: Non-responders showed lower numbers of CD4+/total cells and CD8+/total cells after chemotherapy compared to the responder group, but the difference was not significant (p=0.905, p=0.095). Naïve T, central memory T, effector memory T and effector T-cell counts differed in both groups after chemotherapy. Conclusion: Changes in peripheral T-cell subpopulations after chemotherapy were confirmed in patients with gastric cancer, which may be a prognostic predictor and development of therapeutic agents.