TY - JOUR T1 - Clinical Significance of Composition Changes in T-cell Subpopulations After Chemotherapy in Patients With Gastric Cancer JF - In Vivo JO - In Vivo SP - 2417 LP - 2424 DO - 10.21873/invivo.12519 VL - 35 IS - 4 AU - MIN-KYUNG YEO AU - PUREUM SUN AU - CHAEUK CHUNG AU - JAE HO PARK AU - SUN HYUNG KANG AU - HEE SEOK MOON AU - JAE KYU SUNG AU - HYUN YONG JEONG AU - JU SEOK KIM Y1 - 2021/07/01 UR - http://iv.iiarjournals.org/content/35/4/2417.abstract N2 - Background/Aim: New therapeutic agents and prognostic biomarkers for gastric cancer are needed. We analyzed the composition of peripheral blood T-cell subpopulations in response to chemotherapy in patients with gastric cancer. Patients and Methods: Peripheral blood samples were collected from patients diagnosed with gastric cancer before and after chemotherapy (FOLFOX; oxaliplatin, 5-fluorouracil, and leucovorin). Peripheral blood mononuclear cells were isolated. Patients were divided into responder (n=5) and non-responder groups (n=2) based on their chemotherapy outcomes. Results: Non-responders showed lower numbers of CD4+/total cells and CD8+/total cells after chemotherapy compared to the responder group, but the difference was not significant (p=0.905, p=0.095). Naïve T, central memory T, effector memory T and effector T-cell counts differed in both groups after chemotherapy. Conclusion: Changes in peripheral T-cell subpopulations after chemotherapy were confirmed in patients with gastric cancer, which may be a prognostic predictor and development of therapeutic agents. ER -