PT  - JOURNAL ARTICLE
AU  - MIN-KYUNG YEO
AU  - PUREUM SUN
AU  - CHAEUK CHUNG
AU  - JAE HO PARK
AU  - SUN HYUNG KANG
AU  - HEE SEOK MOON
AU  - JAE KYU SUNG
AU  - HYUN YONG JEONG
AU  - JU SEOK KIM
TI  - Clinical Significance of Composition Changes in T-cell Subpopulations After Chemotherapy in Patients With Gastric Cancer
AID  - 10.21873/invivo.12519
DP  - 2021 Jul 01
TA  - In Vivo
PG  - 2417--2424
VI  - 35
IP  - 4
4099  - http://iv.iiarjournals.org/content/35/4/2417.short
4100  - http://iv.iiarjournals.org/content/35/4/2417.full
SO  - In Vivo2021 Jul 01; 35
AB  - Background/Aim: New therapeutic agents and prognostic biomarkers for gastric cancer are needed. We analyzed the composition of peripheral blood T-cell subpopulations in response to chemotherapy in patients with gastric cancer. Patients and Methods: Peripheral blood samples were collected from patients diagnosed with gastric cancer before and after chemotherapy (FOLFOX; oxaliplatin, 5-fluorouracil, and leucovorin). Peripheral blood mononuclear cells were isolated. Patients were divided into responder (n=5) and non-responder groups (n=2) based on their chemotherapy outcomes. Results: Non-responders showed lower numbers of CD4+/total cells and CD8+/total cells after chemotherapy compared to the responder group, but the difference was not significant (p=0.905, p=0.095). Naïve T, central memory T, effector memory T and effector T-cell counts differed in both groups after chemotherapy. Conclusion: Changes in peripheral T-cell subpopulations after chemotherapy were confirmed in patients with gastric cancer, which may be a prognostic predictor and development of therapeutic agents.