TY - JOUR T1 - Non-melanoma Skin Cancer Treated by Contact High-dose-rate Radiotherapy (Brachytherapy): A Mono-institutional Series and Literature Review JF - In Vivo JO - In Vivo SP - 2313 LP - 2319 DO - 10.21873/invivo.12505 VL - 35 IS - 4 AU - LUCA TAGLIAFERRI AU - FRANCESCO GIUSEPPE CIARDO AU - BRUNO FIONDA AU - CALOGERO CASÀ AU - ALESSANDRO DI STEFANI AU - VALENTINA LANCELLOTTA AU - ELISA PLACIDI AU - GABRIELLA MACCHIA AU - NIKOLA DINO CAPOCCHIANO AU - ALESSIO GIUSEPPE MORGANTI AU - GYÖRGY KOVÁCS AU - FRANCESCO BUSSU AU - KETTY PERIS AU - VINCENZO VALENTINI Y1 - 2021/07/01 UR - http://iv.iiarjournals.org/content/35/4/2313.abstract N2 - Background/Aim: Non-melanoma skin cancers (NMSC) are the most common neoplasms worldwide and their incidence has been proven to increase in recent years and their treatment should aim at cancer cure as well as cosmetic and functional results. The aim of the study was to report the results of our mono-institutional series of high-dose-rate radiotherapy (cHDR-RT) in NMSC, based on a homogenous technique and two different treatment schedules. Patients and Methods: All patients affected by NMSC who were consecutively evaluated and treated at our Interventional Oncology Center from October 2018 to August 2020, were included. Patients underwent cHDR-RT using flap applicators and remotely afterloaded Ir-192 sources. Results: Overall, 51 patients were treated for a total of 67 lesions. Local control (LC) and disease-specific survival (DSS) were 94.0% and 100%, respectively. Grade 1, grade 2, grade 3 and grade 4 acute toxicity rates were 24.6%, 3.5%, 3.5%, and 0.0%, respectively. The cosmetic results were graded as excellent/good, fair, and poor in 73.7%, 19.3%, and 7.0%. Conclusion: cHDR-RT of NMSC is an effective alternative to surgery due to excellent outcomes both in terms of local control and aesthetic results especially in the face. ER -