TY - JOUR T1 - A Gender Comparison of Bone Metabolic Changes After Gastric Cancer Surgery: A Prospective Observational Study JF - In Vivo JO - In Vivo SP - 2341 LP - 2348 DO - 10.21873/invivo.12510 VL - 35 IS - 4 AU - YOSUKE ATSUMI AU - YASUSHI RINO AU - TORU AOYAMA AU - NAOKO OKUDA AU - SHINNOSUKE KAWAHARA AU - KEISUKE KAZAMA AU - MASAKATSU NUMATA AU - HIROSHI TAMAGAWA AU - TAKASHI OSHIMA AU - NORIO YUKAWA AU - MUNETAKA MASUDA Y1 - 2021/07/01 UR - http://iv.iiarjournals.org/content/35/4/2341.abstract N2 - Background/Aim: This study was designed to investigate gender-related differences in changes in bone metabolism after gastric cancer surgery. Patients and Methods: We prospectively recruited 47 patients (38 males and 9 females) who had early gastric cancer. The bone mineral density (BMD), serum levels of 1,25-dihydroxy vitamin D (1,25(OH)2VD), 25-hydroxy vitamin D (25(OH)VD), and estradiol (E2) were measured before and after surgery. Results: BMD significantly decreased 12 months after surgery by median degrees of 3.4% and 3.9% in male and female patients, respectively (p<0.001 and p=0.023). There was no significant difference between both genders in the rate of change in BMD after surgery. The serum E2 level in male patients significantly increased by a median value of 22 pg/ml 12 months after gastrectomy (p=0.030). Both the serum 25(OH)VD and 1,25(OH)2VD levels remained nearly within the normal range throughout the observation period in both male and female patients. Conclusion: BMD significantly decreased within 12 months after gastrectomy in both male and female patients with gastric cancer, and there was no significant gender-related difference in the rate of change in BMD. ER -