PT  - JOURNAL ARTICLE
AU  - ROLANDAS ZABLOCKIS
AU  - EDVARDAS DANILA
AU  - VYGANTAS GRUSLYS
AU  - GIEDRĖ CINCILEVIČIŪTĖ
TI  - Systemic Inflammatory Response to Different Sclerosing Agents as a Predictor of Pleurodesis Outcome
AID  - 10.21873/invivo.12516
DP  - 2021 Jul 01
TA  - In Vivo
PG  - 2391--2398
VI  - 35
IP  - 4
4099  - http://iv.iiarjournals.org/content/35/4/2391.short
4100  - http://iv.iiarjournals.org/content/35/4/2391.full
SO  - In Vivo2021 Jul 01; 35
AB  - Background/Aim: The objectives of this study were to evaluate systemic inflammation using different sclerosing agents and to estimate the prediction of systemic inflammation for the efficacy of pleurodesis. Patients and Methods: Ninety-six patients with recurrent and symptomatic malignant pleural effusion were enrolled in this retrospective study. We used serum C-reactive protein (CRP) levels, serum leukocyte counts and neutrophil-to-lymphocyte ratios (NLRs) as parameters of systemic inflammatory reactions. Evaluations of these parameters were performed before and 24 h after pleurodesis. Results: Pleurodesis was successful in 81 (84.4%) patients. The non-graded talc induced the highest changes in serum CRP levels, total white blood cell and neutrophil counts compared to other agents, while mitoxantrone induced the lowest. Graded talc and bleomycin induced the same levels of changes in serum CRP levels and serum leukocyte counts. The change in serum NLR was the same for all agent groups. Logistic regression confirmed that a change in serum CRP levels [odds ratio (OR)=0.92, p=0.002] and previous chemotherapy (OR=3.31, p=0.012) were independent predictors of pleurodesis efficacy. Conclusion: Pleurodesis agents induced a systemic inflammatory response at different levels. The change in serum CRP levels could be useful for predicting the success of pleurodesis.