RT Journal Article
SR Electronic
T1 Role of S100A4 in the Pathogenesis of Human Periapical Granulomas
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2099
OP 2106
DO 10.21873/invivo.12479
VO 35
IS 4
A1 TAKAHITO TAMURA
A1 TAIKI MIYATA
A1 KEISUKE HATORI
A1 KAZUMA HIMI
A1 TAKESHI NAKAMURA
A1 YURIKA TOYAMA
A1 OSAMU TAKEICHI
YR 2021
UL http://iv.iiarjournals.org/content/35/4/2099.abstract
AB Background/Aim: S100A4 expression is associated with the pathology of chronic inflammatory diseases. In this study, we investigated the role of S100A4 and four inflammatory mediators (IL-1β, IκB, IL-10, and TNF-α) in human periapical granulomas (PGs). Materials and Methods: S100A4 expression in PGs obtained by apicoectomy was examined by immunohistochemistry. Further, the expression of S100A4 and four inflammatory mediators was compared between PGs and healthy gingival tissues (HGTs) using real-time PCR. Results: In the PGs, S100A4 was found to be expressed in endothelial cells and fibroblasts. Furthermore, real-time PCR revealed that the expression of S100A4 and IL-1β in PGs was significantly higher than that in HGTs. Although a correlation between the expression of S100A4 and IκB or IL-10 was not detected, a positive correlation between the expression of S100A4 and IL-1β or TNF-α was observed. Conclusion: The expression of S100A4 correlates with the pathogenesis of PGs.