TY - JOUR T1 - Clinical Outcome After Replacement of Distal Femur/Proximal Tibia in a Heterogeneous Patient Cohort: Function Following Tumour, Trauma, and Loosening JF - In Vivo JO - In Vivo SP - 2275 LP - 2281 DO - 10.21873/invivo.12500 VL - 35 IS - 4 AU - TILMAN GRAULICH AU - CAROLINE KRANZ AU - CHRISTOPH KORALLUS AU - MARCUS OERGEL AU - OMAR-TAREK PACHA AU - MOHAMED OMAR AU - EMMANOUIL LIODAKIS AU - CHRISTIAN KRETTEK AU - MARTIN PANZICA Y1 - 2021/07/01 UR - http://iv.iiarjournals.org/content/35/4/2275.abstract N2 - Background: Distal femur and proximal tibia replacements as limb-salvage procedures with good outcome parameters for patients with tumours have been broadly described. However, the overall midterm outcome in a mixed, heterogeneous patient collective is still unclear. Patients and Methods: We retrospectively analysed 59 consecutive patients (33 for primary and 26 for revision surgery) between 1998 and 2017. Indication for implantation was tumour (n=16), periprosthetic fracture (n=14), traumatic fracture (n=14), infection (n=10), aseptic loosening (n=3), and pathological fracture (n=2). The mean follow-up duration was 3 years. Clinical functions were evaluated by Toronto Extremity Salvage Score and Knee Society Score. Knee extension and flexion force were measured. Results: The overall survival rate of arthroplasties was 59% (n=35). Major complications were observed in 36 (61%) patients. During the follow-up period, 14 (24%) patients died. We recorded periprosthetic joint infection in 21 (36%) patients, recurrence of tumour in two (3%), and aseptic implant failure in three (5%). The mean Toronto Extremity Salvage Score was 66±33, and the mean Knee Society Score was 49±30. The mean extension force on the operated side was significantly reduced at 60° and 180° compared to the healthy side (p=0.0151 and p=0.0411, respectively). Conclusion: Distal femur and proximal tibia replacements showed limited clinical function in a heterogeneous patient collective. Indication for implantation should be considered carefully. ER -