TY - JOUR T1 - The Association of <em>Matrix Metalloproteinase-1</em> Promoter Polymorphisms with Breast Cancer JF - In Vivo JO - In Vivo SP - 487 LP - 491 VL - 32 IS - 3 AU - CHIEH-LUN HSIAO AU - LIANG-CHIH LIU AU - TZU-CHING SHIH AU - YI-LIANG LAI AU - SHIH-WEI HSU AU - HWEI-CHUNG WANG AU - SU-YI PAN AU - TE-CHUN SHEN AU - CHIA-WEN TSAI AU - WEN-SHIN CHANG AU - CHEN-HSIEN SU AU - TZONG-DER WAY AU - JING-GUNG CHUNG AU - DA-TIAN BAU Y1 - 2018/05/01 UR - http://iv.iiarjournals.org/content/32/3/487.abstract N2 - Background/Aim: The family of matrix metalloproteinases (MMPs) are responsible for the homeostasis of extracellular matrix components and their genetic polymorphisms may be associated with cancer susceptibility. The serum levels of MMP-1 have been reported to be lower in breast cancer patients than healthy subjects. In the current study, we aimed at investigating the contribution of a polymorphism in the promoter region of MMP-1 to breast cancer in Taiwan. Materials and Methods: The MMP-1 rs1799705 polymorphic genotypes were genotyped among 1,232 breast cancer patients and 1,232 healthy controls by the typical polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The percentages of 2G/2G, 1G/2G, and 1G/1G for MMP1 -1607 genotypes were 35.4, 40.6 and 24.0% in the breast cancer group and 34.1, 43.6, and 22.3% in the healthy control group (p trend=0.3025), respectively. The odds ratios (ORs) after adjusting for age, smoking and alcohol drinking status for those carrying 1G/2G and 1G/1G genotypes at MMP1 -1607 were 0.93 (95%CI=0.76-1.11, p=0.2390) and 1.01 (95%CI=0.77-1.23, p=0.7377), respectively, compared to those carrying the wild-type 2G/2G genotype. Supporting this finding, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 1.03 (95%CI=0.91-1.18, p=0.8860), compared to those carrying the wild-type 2G allele. Our findings suggest that the polymorphic genotypes at MMP1 promoter -1607 investigated in the current study, may not play a major role in determining cancer susceptibility to breast cancer in Taiwan. Other early diagnostic and predictive markers are urgently needed for personalized and precise breast cancer detection and therapy. ER -