TY - JOUR T1 - PD-1 Expression and its Correlation With Prognosis in Clear Cell Renal Cell Carcinoma JF - In Vivo JO - In Vivo SP - 1549 LP - 1553 DO - 10.21873/invivo.12409 VL - 35 IS - 3 AU - MIN HYE KIM AU - GYUNG HYUK KO AU - JEONG HEE LEE AU - JONG SIL LEE AU - DONG CHUL KIM AU - JUNG WOOK YANG AU - HYO JUNG AN AU - JI MIN NA AU - DAE HYUN SONG Y1 - 2021/05/01 UR - http://iv.iiarjournals.org/content/35/3/1549.abstract N2 - Background/Aim: Programmed death ligand-1 (PD-L1) and programmed death protein 1 (PD-1) expression levels in many tumors and their correlation with prognosis have been actively studied. However, studies on PD-1 expression and its prognostic value in clear cell renal cell carcinoma (ccRCC) are limited and controversial. In this study, we describe the expression of PD-1 and its prognostic significance and association with clinical features in patients with ccRCC. Materials and Methods: We obtained clinicopathological data from 166 patients with ccRCC who were treated at Gyeongsang National University Hospital, Jinju, Korea between January 2000 and December 2009. Tissue microarray blocks were made using representative paraffin blocks of ccRCC specimens. Two pathologists analyzed PD-L1 and PD-1 expression in both tumor and inflammatory cells. Results: PD-1 expression in tumor-infiltrating inflammatory cells was significantly correlated with unfavorable disease-free survival (DFS) (p<0.001) and disease-specific survival (DSS) (p=0.002) in univariate analysis. A statistically significant correlation between PD-1 expression and unfavorable DFS (p=0.025) was observed in the multivariate analysis. Conclusion: PD-1 expression in tumor-infiltrating inflammatory cells serves as an independent prognostic factor for unfavorable DSS in patients with ccRCC. ER -