TY - JOUR T1 - Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer JF - In Vivo JO - In Vivo SP - 1693 LP - 1701 DO - 10.21873/invivo.12429 VL - 35 IS - 3 AU - JUNKI HARADA AU - YASUYOSHI MIYATA AU - KYOHEI ARAKI AU - TSUYOSHI MATSUDA AU - YOSHIAKI NAGASHIMA AU - YUTA MUKAE AU - KENSUKE MITSUNARI AU - TOMOHIRO MATSUO AU - KOJIRO OHBA AU - YASUSHI MOCHIZUKI AU - HIDEKI SAKAI Y1 - 2021/05/01 UR - http://iv.iiarjournals.org/content/35/3/1693.abstract N2 - Background/Aim: The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that of TSP-3, 4 and 5 remains unclear. Our aim is to clarify the pathological significance and prognostic roles of TSP-3 to 5 expression in BC patients. Patients and Methods: TSP-3 to 5 expression, proliferation index (PI), apoptotic index (AI) and microvessel density (MVD) were evaluated in 206 BC patients by immunohistochemical techniques. Results: TSP-5 expression was positively associated with grade, T stage, metastasis, and worse prognosis. PI in TSP-5-positive tissues was significantly higher compared to negative tissues. In contrast, AI in TSP-5-positive tissues was significantly lower compared to negative tissues. Expressions of TSP-3 and 4 were not associated with any clinicopathological features, survival, PI, or AI. Conclusion: TSP-5 plays important roles in malignant behavior via cell survival regulation whereas the pathological significance of TSP-3 and TSP-4 in BC might be minimal. ER -