@article {HARADA1693, author = {JUNKI HARADA and YASUYOSHI MIYATA and KYOHEI ARAKI and TSUYOSHI MATSUDA and YOSHIAKI NAGASHIMA and YUTA MUKAE and KENSUKE MITSUNARI and TOMOHIRO MATSUO and KOJIRO OHBA and YASUSHI MOCHIZUKI and HIDEKI SAKAI}, title = {Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer}, volume = {35}, number = {3}, pages = {1693--1701}, year = {2021}, doi = {10.21873/invivo.12429}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that of TSP-3, 4 and 5 remains unclear. Our aim is to clarify the pathological significance and prognostic roles of TSP-3 to 5 expression in BC patients. Patients and Methods: TSP-3 to 5 expression, proliferation index (PI), apoptotic index (AI) and microvessel density (MVD) were evaluated in 206 BC patients by immunohistochemical techniques. Results: TSP-5 expression was positively associated with grade, T stage, metastasis, and worse prognosis. PI in TSP-5-positive tissues was significantly higher compared to negative tissues. In contrast, AI in TSP-5-positive tissues was significantly lower compared to negative tissues. Expressions of TSP-3 and 4 were not associated with any clinicopathological features, survival, PI, or AI. Conclusion: TSP-5 plays important roles in malignant behavior via cell survival regulation whereas the pathological significance of TSP-3 and TSP-4 in BC might be minimal.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/35/3/1693}, eprint = {https://iv.iiarjournals.org/content/35/3/1693.full.pdf}, journal = {In Vivo} }