PT  - JOURNAL ARTICLE
AU  - CĂLIN SCHIAU
AU  - DANIEL-CORNELIU LEUCUȚA
AU  - SORIN MARIAN DUDEA
AU  - SIMONA MANOLE
TI  - Myocardial Fibrosis as a Predictor of Ventricular Arrhythmias in Patients With Non-ischemic Cardiomyopathy
AID  - 10.21873/invivo.12427
DP  - 2021 May 01
TA  - In Vivo
PG  - 1677--1685
VI  - 35
IP  - 3
4099  - http://iv.iiarjournals.org/content/35/3/1677.short
4100  - http://iv.iiarjournals.org/content/35/3/1677.full
SO  - In Vivo2021 May 01; 35
AB  - Background/Aim: The aim of the study was to assess the relationship between myocardial fibrosis characteristics (percentage, localization, heterogeneity), evaluated by a non-invasive method such as cardiac magnetic resonance (CMR), with the extrasystolic ventricular arrhythmia in patients with non-ischemic cardiomyopathy. Patients and Methods: The study prospectively included 173 consecutive patients who underwent electrocardiogram Holter monitoring, transthoracic echocardiography and CMR with late gadolinium enhancement (LGE). Results: In univariate analysis, both the presence (OR=1.05, 95% CI=1.01-1.09; p=0.015), the percentage of fibrosis >15% (p=0.018), the septum size, the fibrosis in either lateral or septal walls (p=0.004), as well as fibrosis in the midwall (p=0.019) were statistically significant higher in the group with extrasystolic arrhythmia. After adjustment, the percentage of fibrosis >15%, had higher odds of extra systolic arrhythmia [OR=3.78 (95% CI=1.52-10.62, p=0.007)]. Conclusion: The presence, percentage, and localisation of left ventricle myocardial fibrosis characterized by LGE-CMR was associated with ventricular arrhythmias.