TY - JOUR T1 - Ultrasound Echogenicity of Papillary Thyroid Cancer Is Affected by Tumor Growth Patterns and Tumor Fibrosis JF - In Vivo JO - In Vivo SP - 1633 LP - 1640 DO - 10.21873/invivo.12421 VL - 35 IS - 3 AU - YUN-SUNG LIM AU - YOON SE LEE AU - JIN-CHOON LEE AU - SEOK-MAN SON AU - DONG-HOON SHIN AU - SANG SOO KIM AU - IN-JU KIM AU - BYUNG-JOO LEE Y1 - 2021/05/01 UR - http://iv.iiarjournals.org/content/35/3/1633.abstract N2 - Background/Aim: The association between preoperative ultrasound (US) echogenicity and histopathological characteristics of papillary thyroid cancer (PTC) has been rarely investigated is not well characterized. This study evaluated a relationship between the clinical characteristics of PTC, histopathological phenomena including tumor growth patterns (TGPs) and tumor fibrosis (TF), and US echogenicity. Patients and Methods: In total, 170 patients with PTC (<2 cm) underwent total thyroidectomy with central neck dissection. Demographics, US echogenicity, tumor size, extra-thyroidal extension (ETE), lymph node metastasis (LNM) within the central and lateral neck, TGPs, and TF percentage were reviewed. Results: Patients with TGP II (encapsulated growth with partial pericapsular extension) and III (infiltrative growth) were more frequently burdened by ETE and lateral neck LNM compared to patients with TGP I (encapsulated growth with a well-defined cystic or solid characteristic). Older age was significantly deterministic of TGP III, and male gender and higher TF percentage were independent risk factors for lateral neck LNM. TGP III and TF were independent determining factors for marked hypoechogenicity on US. Conclusion: PTC with TGP II and III and higher tumor fibrosis exhibited more aggressive clinicopathologic behaviors. TGP III and TF were determinants for marked hypoechogenicity. ER -