RT Journal Article
SR Electronic
T1 Validation of a Graded Prognostic Model in Patients With Brain Metastases Treated With Whole-brain Radiotherapy Instead of Radiosurgery
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1569
OP 1572
DO 10.21873/invivo.12412
VO 35
IS 3
A1 CARSTEN NIEDER
A1 BÅRD MANNSÅKER
A1 ROSALBA YOBUTA
YR 2021
UL http://iv.iiarjournals.org/content/35/3/1569.abstract
AB Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan. Patients and Methods: This was a retrospective single-institution analysis of 249 patients, managed with whole-brain radiotherapy for brain metastases. The sum of scores was calculated as in the Japanese study. The following parameters were included: number of brain metastases, volume of the largest lesion, sex, Karnofsky performance status, primary cancer type, control of primary cancer, and presence of extra-cerebral metastases. Results: Median overall survival was 3.0 months (95% CI= 2.6-3.4 months). The median sum of scores was 12, range=0-29. Statistically significant differences were observed between all prognostic strata. Conclusion: The graded prognostic model is also applicable to patients treated with whole-brain rather than stereotactic radiotherapy.