RT Journal Article
SR Electronic
T1 Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1611
OP 1615
DO 10.21873/invivo.12418
VO 35
IS 3
A1 VASILEIOS PAPANIKOLAOU
A1 ARISTEIDIS CHRYSOVERGIS
A1 STYLIANOS MASTRONIKOLIS
A1 EVANGELOS TSIAMBAS
A1 VASILEIOS RAGOS
A1 DIMITRIOS PESCHOS
A1 DESPOINA SPYROPOULOU
A1 PAVLOS PANTOS
A1 ATHANASIOS NIOTIS
A1 NICHOLAS MASTRONIKOLIS
A1 EFTHYMIOS KYRODIMOS
YR 2021
UL http://iv.iiarjournals.org/content/35/3/1611.abstract
AB Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation is a crucial genetic combination that promotes cell neoplastic phenotype and progressively malignant transformation in solid malignancies, including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten ras oncogene homolog (K-Ras) is involved in LSCC onset and progression. Patients and Methods: Sixty (n=60) primary LSCC tissue sections were analyzed by immunohistochemistry (IHC). Digital image analysis (DIA) was also implemented for measuring K-Ras protein expression levels. Results: High K-Ras protein expression levels were observed in 20/60 (33.3%) LSCC tissue sections, whereas the rest of the cases (n=40; 66.7%) demonstrated low expression. Overall K-Ras expression was borderline significantly associated to the grade of the examined malignancies (p=0.048), whereas no other strong statistical correlations were identified. A progressive K-Ras overexpression was observed in all grades of the examined cases. Conclusion: K-Ras over expression is correlated to a progressive dedifferentiation in LSCC.