@article {PAPANIKOLAOU1611, author = {VASILEIOS PAPANIKOLAOU and ARISTEIDIS CHRYSOVERGIS and STYLIANOS MASTRONIKOLIS and EVANGELOS TSIAMBAS and VASILEIOS RAGOS and DIMITRIOS PESCHOS and DESPOINA SPYROPOULOU and PAVLOS PANTOS and ATHANASIOS NIOTIS and NICHOLAS MASTRONIKOLIS and EFTHYMIOS KYRODIMOS}, title = {Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma}, volume = {35}, number = {3}, pages = {1611--1615}, year = {2021}, doi = {10.21873/invivo.12418}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation is a crucial genetic combination that promotes cell neoplastic phenotype and progressively malignant transformation in solid malignancies, including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten ras oncogene homolog (K-Ras) is involved in LSCC onset and progression. Patients and Methods: Sixty (n=60) primary LSCC tissue sections were analyzed by immunohistochemistry (IHC). Digital image analysis (DIA) was also implemented for measuring K-Ras protein expression levels. Results: High K-Ras protein expression levels were observed in 20/60 (33.3\%) LSCC tissue sections, whereas the rest of the cases (n=40; 66.7\%) demonstrated low expression. Overall K-Ras expression was borderline significantly associated to the grade of the examined malignancies (p=0.048), whereas no other strong statistical correlations were identified. A progressive K-Ras overexpression was observed in all grades of the examined cases. Conclusion: K-Ras over expression is correlated to a progressive dedifferentiation in LSCC.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/35/3/1611}, eprint = {https://iv.iiarjournals.org/content/35/3/1611.full.pdf}, journal = {In Vivo} }