PT - JOURNAL ARTICLE AU - YEON JOO KIM AU - SI YEOL SONG AU - WANLIM KIM AU - JONGSEOK LEE AU - JIN-HEE AHN AU - JEONG EUN KIM AU - HYE WON CHUNG AU - SEONG-YUN JEONG AU - EUN KYUNG CHOI TI - Undervaluation of Radiotherapy for Gross Desmoid Tumors: The Need for Absolute Volume Assessment AID - 10.21873/invivo.12437 DP - 2021 May 01 TA - In Vivo PG - 1777--1784 VI - 35 IP - 3 4099 - http://iv.iiarjournals.org/content/35/3/1777.short 4100 - http://iv.iiarjournals.org/content/35/3/1777.full SO - In Vivo2021 May 01; 35 AB - Background/Aim: To compare absolute volume (AV) assessment according to Response Evaluation Criteria in Solid Tumors (RECIST) for the response evaluation of desmoid tumors (DTs) treated with radiotherapy. Patients and Methods: Eighteen patients with DTs ≥3 cm in size were included. Results: The median follow-up duration was 78.0 months. Five patients achieved a complete response according to RECIST, seven reached a partial response (PR), and one eventually exhibited progression. The overall response rate was 61%, the median time to PR was 8.0 months. Six patients achieved stable disease, although three developed progressions. Of the six patients with a PR, the median change in maximum diameter was −46%, and the median change in maximum volume was −84%. Three patients could have been diagnosed with progression at least 6 months earlier if the AV increment was considered. Conclusion: An AV assessment is essential for an accurate response assessment of DTs and radiotherapy seems feasible as a first-line treatment for DTs.