RT Journal Article
SR Electronic
T1 Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1749
OP 1760
DO 10.21873/invivo.12434
VO 35
IS 3
A1 MASAMICHI HAYASHI
A1 SUGURU YAMADA
A1 NAO TAKANO
A1 YUKIYASU OKAMURA
A1 HIDEKI TAKAMI
A1 YOSHIKUNI INOKAWA
A1 FUMINORI SONOHARA
A1 NOBUTAKE TANAKA
A1 DAI SHIMIZU
A1 NORIFUMI HATTORI
A1 MITSURO KANDA
A1 CHIE TANAKA
A1 GORO NAKAYAMA
A1 MASAHIKO KOIKE
A1 YASUHIRO KODERA
YR 2021
UL http://iv.iiarjournals.org/content/35/3/1749.abstract
AB Background/Aim: Hepatocellular carcinoma (HCC) mainly develops in the damaged liver from hepatitis C virus (HCV) or hepatitis B virus (HBV) infection in Japan. On the other hand, the occurrence of HCCs derived from the liver without viral infection has recently been increasing. Our aim was to identify characteristics specific to HCCs with virus-infected liver (HCC-BC) or those with non-B- and non-C-infected liver (HCC-NBNC), Patients and Methods: We collected preoperative serum α-fetoprotein (AFP) and Des-Gamma-Carboxy Prothrombin (DCP), also known as PIVKA-II values from surgically resected HCC cases during 1994-2017 in our department. Results: Preoperative serum AFP values of HCC-BC cases (n=284) were higher compared to HCC-NBNC cases (n=88) (p=0.016), whereas serum DCP values of HCC-NBNC cases were higher compared to HCC-BC cases (p<0.001). Multivariable analyses indicated that abnormal serum AFP [hazard ratio (HR)=1.46, 95% conficdence interval (CI)=1.03-2.07, p=0.035) was one of the significant recurrence-free survival predictors of HCC-BC cases, while abnormal serum DCP (HR=4.99, 95%CI=1.91-13.01, p=0.001) was one of the significant recurrence-free survival predictors of HCC-NBNC cases. Conclusion: HCC-NBNC cases have a different tumor marker profile from HCC-BC cases. Elevated DCP could be both a diagnostic and prognostic marker of HCC-NBNC patients.