RT Journal Article
SR Electronic
T1 Thrombotic Microangiopathy: A Rare Breast Cancer-associated Complication Treated Successfully With Doxorubicin and Cyclophosphamide
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1885
OP 1888
DO 10.21873/invivo.12452
VO 35
IS 3
A1 SAMUEL JALALI
A1 DAKOTA JENNEMAN
A1 ANKITA TANDON
A1 HUNG KHONG
YR 2021
UL http://iv.iiarjournals.org/content/35/3/1885.abstract
AB Background: Thrombotic microangiopathy (TMA) is a clinical syndrome consisting of hemolytic anemia, thrombocytopenia, and presence of schistocytes on peripheral blood smear secondary to disorders of systemic microvascular thrombosis. Malignancy-associated TMA is a rare entity and shares clinical features with that of HUS and TTP usually seen in patients with metastatic cancer, tumor cell infiltration of the bone marrow and/or response to cancer-directed therapy. Case Report: We present a rare case of TMA secondary to breast cancer without evidence of bone marrow infiltration responsive to doxorubicin and cyclophosphamide treatment, after failed plasmapheresis with prednisone and later, eculizumab. Conclusion: Despite being a rare manifestation of metastatic carcinoma, early identification and treatment are essential to improving survival.