TY - JOUR T1 - Thrombotic Microangiopathy: A Rare Breast Cancer-associated Complication Treated Successfully With Doxorubicin and Cyclophosphamide JF - In Vivo JO - In Vivo SP - 1885 LP - 1888 DO - 10.21873/invivo.12452 VL - 35 IS - 3 AU - SAMUEL JALALI AU - DAKOTA JENNEMAN AU - ANKITA TANDON AU - HUNG KHONG Y1 - 2021/05/01 UR - http://iv.iiarjournals.org/content/35/3/1885.abstract N2 - Background: Thrombotic microangiopathy (TMA) is a clinical syndrome consisting of hemolytic anemia, thrombocytopenia, and presence of schistocytes on peripheral blood smear secondary to disorders of systemic microvascular thrombosis. Malignancy-associated TMA is a rare entity and shares clinical features with that of HUS and TTP usually seen in patients with metastatic cancer, tumor cell infiltration of the bone marrow and/or response to cancer-directed therapy. Case Report: We present a rare case of TMA secondary to breast cancer without evidence of bone marrow infiltration responsive to doxorubicin and cyclophosphamide treatment, after failed plasmapheresis with prednisone and later, eculizumab. Conclusion: Despite being a rare manifestation of metastatic carcinoma, early identification and treatment are essential to improving survival. ER -