PT  - JOURNAL ARTICLE
AU  - SAMUEL JALALI
AU  - DAKOTA JENNEMAN
AU  - ANKITA TANDON
AU  - HUNG KHONG
TI  - Thrombotic Microangiopathy: A Rare Breast Cancer-associated Complication Treated Successfully With Doxorubicin and Cyclophosphamide
AID  - 10.21873/invivo.12452
DP  - 2021 May 01
TA  - In Vivo
PG  - 1885--1888
VI  - 35
IP  - 3
4099  - http://iv.iiarjournals.org/content/35/3/1885.short
4100  - http://iv.iiarjournals.org/content/35/3/1885.full
SO  - In Vivo2021 May 01; 35
AB  - Background: Thrombotic microangiopathy (TMA) is a clinical syndrome consisting of hemolytic anemia, thrombocytopenia, and presence of schistocytes on peripheral blood smear secondary to disorders of systemic microvascular thrombosis. Malignancy-associated TMA is a rare entity and shares clinical features with that of HUS and TTP usually seen in patients with metastatic cancer, tumor cell infiltration of the bone marrow and/or response to cancer-directed therapy. Case Report: We present a rare case of TMA secondary to breast cancer without evidence of bone marrow infiltration responsive to doxorubicin and cyclophosphamide treatment, after failed plasmapheresis with prednisone and later, eculizumab. Conclusion: Despite being a rare manifestation of metastatic carcinoma, early identification and treatment are essential to improving survival.