@article {LAI1083, author = {GU-SHUN LAI and JIAN-RI LI and SHIAN-SHIANG WANG and CHUAN-SHU CHEN and CHUN-KUANG YANG and SHENG-CHUN HUNG and CHEN-LI CHENG and YEN-CHUAN OU and KUN-YUAN CHIU}, title = {Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma}, volume = {35}, number = {2}, pages = {1083--1089}, year = {2021}, doi = {10.21873/invivo.12353}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. Patients and Methods: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. Results: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95\% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95\% CI=1.01-6.0, p=0.048). Conclusion: For patients with T3a renal tumors, RVI was associated with inferior prognosis compared to those with FI.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/35/2/1083}, eprint = {https://iv.iiarjournals.org/content/35/2/1083.full.pdf}, journal = {In Vivo} }