RT Journal Article SR Electronic T1 Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency In Vivo JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 779 OP 791 DO 10.21873/invivo.12318 VO 35 IS 2 A1 HISATAKA KITANO A1 YOH MASAOKA A1 ATSUSHI MAMIYA A1 YUSUKE FUJIWARA A1 TOSHIO MIKI A1 CHIAKI HIDAI YR 2021 UL http://iv.iiarjournals.org/content/35/2/779.abstract AB Background/Aim: Combination cancer therapy is currently under investigation. This study examined the effect of cancer combination therapy using the E3 and C1 (E3C1) domains of developmental endothelial locus-1 (Del1) and cisplatin (CDDP) in murine transplanted tumors. Materials and Methods: Mice with transplanted tumors (A431, SCCKN or SCC-4 cells) were injected intraperitoneally with CDDP and injected locally with nonviral plasmid vectors encoding E3C1. Histochemical analysis of the transplanted tumors was then performed to assess the effects on prognosis. Results: The CDDP+E3C1 injected group had reduced tumor growth and longer survival compared to the CDDP injected group. In addition, cell death was observed in the tumor of the CDDP+E3C1 group.. Furthermore, angiogenesis and increased blood vessels were observed together with stromal development. Conclusion: The CDDP+E3C1 treatment resulted in improved survival and poor tumor stromal development in mice with transplanted tumors.