PT  - JOURNAL ARTICLE
AU  - HISATAKA KITANO
AU  - YOH MASAOKA
AU  - ATSUSHI MAMIYA
AU  - YUSUKE FUJIWARA
AU  - TOSHIO MIKI
AU  - CHIAKI HIDAI
TI  - Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency <em>In Vivo</em>
AID  - 10.21873/invivo.12318
DP  - 2021 Mar 01
TA  - In Vivo
PG  - 779--791
VI  - 35
IP  - 2
4099  - http://iv.iiarjournals.org/content/35/2/779.short
4100  - http://iv.iiarjournals.org/content/35/2/779.full
SO  - In Vivo2021 Mar 01; 35
AB  - Background/Aim: Combination cancer therapy is currently under investigation. This study examined the effect of cancer combination therapy using the E3 and C1 (E3C1) domains of developmental endothelial locus-1 (Del1) and cisplatin (CDDP) in murine transplanted tumors. Materials and Methods: Mice with transplanted tumors (A431, SCCKN or SCC-4 cells) were injected intraperitoneally with CDDP and injected locally with nonviral plasmid vectors encoding E3C1. Histochemical analysis of the transplanted tumors was then performed to assess the effects on prognosis. Results: The CDDP+E3C1 injected group had reduced tumor growth and longer survival compared to the CDDP injected group. In addition, cell death was observed in the tumor of the CDDP+E3C1 group.. Furthermore, angiogenesis and increased blood vessels were observed together with stromal development. Conclusion: The CDDP+E3C1 treatment resulted in improved survival and poor tumor stromal development in mice with transplanted tumors.